DO. NOT. name every single character of your book with a weird name *and* a strange nickname. If I have to wade through Jeremiah "Nostril" Fluffenbuffer having a conversation with "Pork Chop" Hepzibah Snogglebastermeier as they chase after Zelda "Twinkle Toes" Latishanda Grogglesnow and her best friend, Matilda "Princess" Eliana Schoenblad (See? You have a headache already just wading through that sentence don't you?), then I will throw your book across the room and say things my children shouldn't hear and it will all be your fault.
And I just might rant about it on my blog.